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Sriram Balasubramanian Selected Research

abexinostat

3/2016A Phase I/II Multicenter, Open-Label Study of the Oral Histone Deacetylase Inhibitor Abexinostat in Relapsed/Refractory Lymphoma.
4/2015Phase 1 study of oral abexinostat, a histone deacetylase inhibitor, in combination with doxorubicin in patients with metastatic sarcoma.
1/2010PCI-24781, a Novel Hydroxamic Acid HDAC Inhibitor, Exerts Cytotoxicity and Histone Alterations via Caspase-8 and FADD in Leukemia Cells.
5/2009PCI-24781 induces caspase and reactive oxygen species-dependent apoptosis through NF-kappaB mechanisms and is synergistic with bortezomib in lymphoma cells.
5/2006CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo.

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Sriram Balasubramanian Research Topics

Disease

12Neoplasms (Cancer)
01/2022 - 05/2006
10Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
12/2021 - 06/2012
6B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
12/2021 - 02/2016
5Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)
01/2022 - 03/2016
5Non-Hodgkin Lymphoma (Lymphosarcoma)
01/2020 - 05/2009
4Lymphoma (Lymphomas)
11/2021 - 05/2009
3Disease Progression
12/2020 - 04/2015
3Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
01/2020 - 02/2016
2Neutropenia
02/2016 - 04/2015
2Hodgkin Disease (Hodgkin's Disease)
10/2015 - 05/2009
1Asphyxia (Suffocation)
12/2020
1Ventricular Fibrillation
12/2020
1Residual Neoplasm
01/2020
1Exanthema (Rash)
02/2019
1Scoliosis
03/2018
1Hematologic Neoplasms (Hematological Malignancy)
01/2018
1Congenital Abnormalities (Deformity)
10/2017
1Trisomy (Trisomies)
02/2017
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2017
1Thrombocytopenia (Thrombopenia)
02/2016
1Sarcoma (Soft Tissue Sarcoma)
04/2015
1Leukemia
01/2010
1Colorectal Neoplasms (Colorectal Cancer)
07/2006
1Body Weight (Weight, Body)
05/2006

Drug/Important Bio-Agent (IBA)

19ibrutinibIBA
01/2022 - 08/2014
7Rituximab (Mabthera)FDA Link
01/2021 - 08/2014
5Agammaglobulinaemia Tyrosine KinaseIBA
12/2021 - 08/2014
5Doxorubicin (Adriamycin)FDA LinkGeneric
01/2021 - 08/2014
5abexinostatIBA
03/2016 - 05/2006
4Cyclophosphamide (Cytoxan)FDA LinkGeneric
01/2021 - 08/2014
4Vincristine (Oncovin)FDA LinkGeneric
01/2021 - 08/2014
4Prednisone (Sone)FDA LinkGeneric
01/2021 - 08/2014
4Histone Deacetylase InhibitorsIBA
03/2016 - 05/2009
3Biological ProductsIBA
01/2022 - 01/2020
3NivolumabIBA
11/2021 - 02/2019
3Pharmaceutical PreparationsIBA
03/2016 - 08/2014
3Histone Deacetylases (Histone Deacetylase)IBA
04/2015 - 05/2006
3Histones (Histone)IBA
01/2010 - 05/2006
2Biomarkers (Surrogate Marker)IBA
01/2021 - 01/2020
2Bendamustine HydrochlorideFDA Link
12/2020 - 02/2016
2Protein Isoforms (Isoforms)IBA
01/2020 - 08/2009
2ElementsIBA
03/2018 - 10/2017
2Hydroxamic Acids (Hydroxamic Acid)IBA
01/2010 - 05/2006
2TubulinIBA
07/2006 - 05/2006
1venetoclaxIBA
12/2021
1Circulating Tumor DNAIBA
11/2021
1altersolanol AIBA
11/2021
1carboxyl radical (COO-)IBA
01/2021
1B7-H1 AntigenIBA
01/2021
1Immunoglobulins (Immunoglobulin)IBA
01/2020
1RNA (Ribonucleic Acid)IBA
01/2020
1Immunoglobulin Heavy Chains (Immunoglobulin Heavy Chain)IBA
11/2019
1Alanine Transaminase (SGPT)IBA
02/2019
1Heme (Haem)IBA
01/2018
1temsirolimusFDA Link
02/2016
1InterferonsIBA
06/2012
1Lenalidomide (CC 5013)FDA Link
06/2012
1Superoxides (Superoxide)IBA
01/2010
1Caspase 8 (Caspase-8)IBA
01/2010
1Reactive Oxygen Species (Oxygen Radicals)IBA
05/2009
1CaspasesIBA
05/2009
1NF-kappa B (NF-kB)IBA
05/2009
1Proteins (Proteins, Gene)FDA Link
05/2009
1Bortezomib (Velcade)FDA Link
05/2009
1Bevacizumab (Avastin)FDA Link
07/2006
1CRA 026440IBA
07/2006

Therapy/Procedure

10Therapeutics
11/2021 - 01/2010
3Drug Therapy (Chemotherapy)
11/2019 - 04/2015
1Cardiopulmonary Resuscitation (CPR)
12/2020